Key sentence from the paper: “[This study] found no statistically significant difference in the outcome of overall survival, biochemical failure, local progression, distant metastasis or disease-free survival with the addition of chemotherapy using oral etoposide to a regimen of 2 years of androgen suppression + radiation therapy.”

Key sentence from the paper: “[T]here is no increase in the mortality of men treated with [primary androgen deprivation therapy].

Key sentence from the paper: “[O]ur analysis reported a significant increase in cardiac events and hypertension in [metastatic castrate resistant prostate cancer] patients treated with new hormonal therapies.” 

Key sentence from the paper: “ADT with GnRH agonists or orchiectomy increases the risk of fracture in Chinese patients with prostate cancer. However, the magnitude of the increase in risk is seemingly not as large as that in Western populations.”

Key sentence from the paper: “[A]dding docetaxel and estramustine to ADT significantly improved recurrence-free survival compared with ADT alone in patients with high-risk localized prostate cancer, with no apparent long-term toxicity related to chemotherapy.”

Key sentence from the paper: “[P]atients who receive ≥ 8 doses of GnRH agonists and life expectancy of ≥ 5 years were at a significantly higher risk of [sudden cardiac death].”

Key sentence from the paper: “[T]he combination of standard ADT and six cycles of docetaxel resulted in significantly longer overall survival than that with standard ADT alone in men with hormone-sensitive metastatic prostate cancer.”

Key sentence from the paper: “ADT is associated with a higher risk of other cause mortality in patients with PCa. This harmful association was most evident in healthier patients, and those with long-term ADT use.”

Key sentence from the paper: “[S]trength training had beneficial effects on muscle cellular outcomes in PCa patients on ADT and is therefore recommended.”

Key sentence from the paper: “…The historic T [testosterone] target for ADT of ≤ 50 ng/dl is too high, given that surgical castration results in T levels < 20 ng/dl, and significant improvements in clinical outcomes for patients meeting lower serum T thresholds have been demonstrated.”