Key sentence from the paper: “In the absence of a survival advantage in favor of either strategy [i.e., continuous vs. intermittent ADT] any advantage of intermittent ADT is likely to be limited to possible improvements in [quality of life] particularly during the off-treatment period; convenience of therapy; and savings in cost.”

Key sentence from the paper: “Our statistical analysis shows an increase of [overall survival] for patients treated with docetaxel-based chemotherapy plus ADT in comparison with ADT alone.”

Key sentence from the paper: “… patients with ADT had a 23% increased risk of depression.”

Key sentence from the paper: “Men treated with ADT responded to the exercise training similarly to men who had not been treated with ADT.”

Key sentence from the paper: “Overall survival was significantly longer in the immediate androgen-deprivation therapy arm compared with the delayed therapy arm.”

Key sentence from the paper: “[T]he skeletal consequences of hypogonadism in men are primarily due to estrogen deficiency.”

Key sentence from the paper: “The physician’s focus should be to optimize the cardiovascular and metabolic risk profile as much as feasible over the course of survivorship.”

Key sentence from the paper: “Transdermal oestradiol as a single agent produces castration levels of testosterone while mitigating [bone mineral density loss].”

Key sentence from the paper: “[A]DT or orchiectomy caused a mild 10% decline in hemoglobin and [red blood cell] counts in men with non-metastatic prostate cancer without anemia prior to receiving treatment… ADT correlated with a decline in mental fatigue surrogate score...”

Key sentence from the paper: “Although the effects of exercise interventions on [quality of life] are apparent, it is unclear whether these improvements are attributable to increased interventionist contact, aerobic exercise, resistance exercise, or the combination of all three..”