Weight gain on androgen deprivation therapy: which patients are at highest risk? By Seible et al. 2014
Concluding summary from the paper: “Age <65 years and BMI <30 were both independently associated with weight gain 1 year after starting ADT.”
For the full abstract, see: http://www.ncbi.nlm.nih.gov/pubmed/24726149
Commentary: It is well known that patients who are overweight and already have cardiovascular health problems, are at risk of more serious problems when they start on ADT. These authors ask a different question: which ADT patients are at greatest risk of gaining weight? They found that men, who are younger than 65 and those who are not obese, are more likely to gain weight on these drugs. The authors encourage healthcare providers to warn young and otherwise healthy that they may actually be at greater risk of gaining weight than men who are overweight, when going on ADT.
Seible DM, Gu X, Hyatt AS, Beard CJ, Choueiri TK, Efstathiou JA, Miyamoto DT, Mitin T, Martin NE, Sweeney CJ, Trinh QD, Beckman JA, Basaria S, Nguyen PL. 2014. Weight gain on androgen deprivation therapy: which patients are at highest risk? Urology 83(6):1316-1321.