Key sentence from the paper: “… for men with no or minimal comorbidity, it appears that the delivery of full versus dose-reduced [anti-androgens] was not associated with prolonged survival…suggesting that supplementing the LHRH agonist therapy with and [anti-androgen] for ~4 rather than 6 months may be sufficient to minimize death from [prostate cancer] and prolong survival as compared with no ADT use.”

Key sentence from the paper: “… Although large–scale RCTs are needed to ascertain the precise exercise prescription necessary to improve [metabolic syndrome] factors arising from ADT administration, patients can still benefit from consistent exercise as improvements in muscle mass, strength, physical function and psychological well-being have been demonstrated.”

Key sentence from the paper: “… we did not find any indication that second-line LHRH analogues resulted in further decrease in PSA even under equivalent low LH and testosterone levels prior to and after switching therapy.”

Key sentence from the paper: “[T]here appears to be an increased risk of death among AA [African American] men with low-risk or favorable intermediate-risk PC [prostate cancer] exposed to a short course of neoadjuvant ADT. Therefore, the use of ADT in AA men should be reserved for treating higher risk PC.”

Key sentence from the paper: “Overall, QoL [quality of life ] is significantly affected within 12 months of commencing ADT for prostate cancer in men undergoing ADT, above that for a cancer diagnosis alone, prostate cancer progression or radiotherapy.”

Key sentence from the paper: “Although there was an increased risk of metabolic syndrome in patients receiving intermittent ADT, it was lower than other studies that treated the same patients with continuous ADT.”

Key sentence from the paper: “The intervention consists of an initial educational session of 1½ hours followed by 12 weeks of group-based supervised training two times a week. The focus of the exercise is progressive resistance training in combination with aerobic training.”

Key sentence from the paper: “Although ADT use was positively correlated with the FRAX score…, the correlation was not so high. We speculate that the relatively weak correlation resulted from the use of the FRAX score for assessment rather than the DEXA score.”

Key sentence from the paper: “…these findings suggest that prostate cancer patients receiving ADT experience high levels of fatigue that is clinically meaningful during the 12 months following ADT initiation.”

Key sentence from the paper: “[Continuous] ADT is inferior to [intermittent] ADT for the treatment of prostate cancer with respect to cardiovascular-related mortality. No major difference in incidence of cardiovascular events and thromboembolic events were observed between the two groups….”