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Key sentence from the paper: “…the IADT group showed consistent reduced risk of these serious toxicities compared to the CADT group in both subgroups with or without comorbidities...”

Key sentence from the paper:  “In contrast to patients with moderate to severe [lower urinary tract symptoms], nocturia showed a significant increase during ADT therapy in patients with mild symptoms.”

Key sentence from the paper: “All clinical trials of newer agents… in [metastatic castrate-resistant prostate cancer] include patients who maintain castrate levels of testosterone, and so clinical practice should adhere to this principle of continuing ADT when initiating abiraterone, enzalutamide or chemotherapy.”

Key sentence from the paper: "The use of ADT is associated with an increased risk of hospitalisation for community-acquired pneumonia in men with prostate cancer.”

Key sentence from the paper: “… treatments with radiotherapy…and ADT…were each independently associated with increased risk of coronary heart disease, sudden cardiac death, fracture, and fracture requiring hospitalization.”

Key sentence from the paper: “Our study extends previous work supporting an association between use of ADT and Alzheimer disease and suggests that ADT may more broadly affect neurocognitive function.”

Key sentence from the paper: “The risk of [prostate cancer specific mortality] significantly decreased with the addition of ADT in the setting of high-dose [radiation therapy] for men with intermediate- or high-risk [prostate cancer] with a low, but not a high [competing mortality] score.”

Key sentence from the paper: “The role of serum [total testosterone] measurement during ADT remains unclear and here we have generated the hypothesis that [free testosterone] determination at 6-month is a better surrogate than [total testosterone] to predict [castrate-resistant prostate cancer] in patients with no metastatic disease.”

Key sentence from the paper: “…in men with known [coronary artery disease], only those with baseline low and lower 1/3 of the normal testosterone had a significantly higher [overall mortality] when they received ADT >6months compared with when they did not.”