ADT Risks and Side Effects in Advanced Prostate Cancer: Cardiovascular and Acute Renal Injury. By Crawford and Moul 2015
Key sentence from the paper: “[It] is noteworthy that the time frames of CV and AKI events recorded during ADT are similar. Also both adverse effects are seen with LHRH agonists but not (or to a lesser extent degree) with anti-androgens and bilateral orchiectomy, suggesting a potential drug class effect.”
For the full abstract, see: http://www.ncbi.nlm.nih.gov/pubmed/25592210
Commentary: The authors of this interesting review offer some speculations on the reason that CV and AKI present in a similar time frame for patients on ADT. They hypothesize about how the activation of the luteinizing hormone-releasing hormone receptors might affect atherosclerotic plaque. Destabilized plagues can move down the circulatory system to clog up both coronary arteries and blood vessels in kidneys, leading to both CV and AKI. It is an interesting hypothesis but more research is needed to know if it is true or not.
Crawford ED, Moul JW. 2015. ADT Risks and Side Effects in Advanced Prostate Cancer: Cardiovascular and Acute Renal Injury. Oncology (Williston Park) 29(1).