Key sentence from the paper: “Evidence of increased emotional lability and depressed mood in men who receive ADT…and the risk of depression in the patient’s partner is discussed. The evidence for adverse cognitive effects with ADT is still emerging but suggests that ADT is associated with impairment in multiple cognitive domains.”

Key sentence from the paper: “…[intermittent ADT] produces a longer duration in median time to [castrate resistant prostate cancer] than does [continuous ADT].”

Key sentence from the paper: “Three months or longer exposure to androgen deprivation therapy was associated with reduced cardiorespiratory capacity and resting metabolic rate.”

Key sentence from the paper: “In patients with high-risk prostate cancer, we observed 6 cases (5.4%) of pT0 disease that showed no tumor recurrence during the follow-up… ADT can induce a complete pathological response, and can potentially eradicate advanced prostate cancer.” 

Key sentence from the paper: “… docetaxel should be considered in routine practice for suitable men with newly diagnosed metastatic disease, and also for selected men with high-risk non-metastatic disease in view of substantial prolongation of [failure-free survival].” 

Key sentence from the paper: “…chronological arguments remain strongest for relating [sleep apnea] to enzalutamide.” 

Key sentence from the paper: “31% of the chemotherapy-naïve patients remained on enzalutamide therapy for >2yr and 17% for >4%. This contrasts with the 2-yr on –treatment rate of 5% for postchemotherapy patients.” 

Key sentence from the paper: “Long-term enzalutamide monotherapy in men with noncastrate [hormone naïve prostate cancer] is associated with large sustained reductions in PSA, signals indicating a favorable tumor response, and favorable safety/tolerability profile.”

Key sentence from the paper: “[men] on ADT experienced greater bother at loss of sexual function than patients not on ADT, suggesting that loss of libido when on ADT does not mitigate the psychological distress associated with loss of erection.” 

Key sentence from the paper: “Both patients and partners report that patients have had significantly worse mood since beginning ADT. Partners reported a larger difference in the patients’ mood than did the patients themselves for all parameters [i.e., depression, anger, fatigue, confusion] except vigor and tension.”